Use ticker rate is related to where you place your orders in the orderbook. Since trading volumes can differ a lot between crypto exchanges and trading pairs, we recommend using 'Highest bid, Lowest ask' to minimize your losses.
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If 'Use last tick if higher or lower' is selected, the sell or buy price will be the last tick value.
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'Always use last tick' takes the price of the last tick, regardless of price fluctuations.
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When trading on trading pairs with low trading volumes, we recommend using Highest bid, Lowest ask as this setting looks at the highest bid or lowest ask values in the orderbook.